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Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

The cleavage model for signal transduction by receptors of the LIN-12/Notch family posits that ligand binding leads to cleavage within the transmembrane domain, so that the intracellular domain is released to translocate to the nucleus and activate target gene expression. The familial Alzheimer'...

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Detalhes bibliográficos
Main Authors: Struhl, Gary, Greenwald, Iva
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC14573/
https://ncbi.nlm.nih.gov/pubmed/11134525
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