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Notch receptor cleavage depends on but is not directly executed by presenilins
Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the intracellular domain into the nucleus to execute Notch signaling. This so-called γ-secretase cleavag...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122640/ https://ncbi.nlm.nih.gov/pubmed/11891288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052017699 |
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