Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

Mouse Notch1, which plays an important role in cell fate determination in development, is proteolytically processed within its transmembrane domain by unidentified γ-secretase-like activity that depends on presenilin. To study this proteolytic event, we established a cell-free Notch cleavage assay s...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Mizutani, Tomohiko, Taniguchi, Yoshihito, Aoki, Tomokazu, Hashimoto, Nobuo, Honjo, Tasuku
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55367/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11459941/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161269998
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