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Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
Mouse Notch1, which plays an important role in cell fate determination in development, is proteolytically processed within its transmembrane domain by unidentified γ-secretase-like activity that depends on presenilin. To study this proteolytic event, we established a cell-free Notch cleavage assay s...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC55367/ https://ncbi.nlm.nih.gov/pubmed/11459941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161269998 |
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