Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

Mouse Notch1, which plays an important role in cell fate determination in development, is proteolytically processed within its transmembrane domain by unidentified γ-secretase-like activity that depends on presenilin. To study this proteolytic event, we established a cell-free Notch cleavage assay s...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Mizutani, Tomohiko, Taniguchi, Yoshihito, Aoki, Tomokazu, Hashimoto, Nobuo, Honjo, Tasuku
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55367/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11459941/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161269998
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