Notch receptor cleavage depends on but is not directly executed by presenilins

Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the intracellular domain into the nucleus to execute Notch signaling. This so-called γ-secretase cleavag...

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Bibliografski detalji
Glavni autori: Taniguchi, Yoshihito, Karlström, Helena, Lundkvist, Johan, Mizutani, Tomohiko, Otaka, Akira, Vestling, Monica, Bernstein, Alan, Donoviel, Dorit, Lendahl, Urban, Honjo, Tasuku
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC122640/
https://ncbi.nlm.nih.gov/pubmed/11891288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052017699
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