Notch receptor cleavage depends on but is not directly executed by presenilins

Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the intracellular domain into the nucleus to execute Notch signaling. This so-called γ-secretase cleavag...

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Библиографические подробности
Главные авторы: Taniguchi, Yoshihito, Karlström, Helena, Lundkvist, Johan, Mizutani, Tomohiko, Otaka, Akira, Vestling, Monica, Bernstein, Alan, Donoviel, Dorit, Lendahl, Urban, Honjo, Tasuku
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2002
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC122640/
https://ncbi.nlm.nih.gov/pubmed/11891288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052017699
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