Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects

Genetic studies in worms, flies, and humans have implicated the presenilins in the regulation of the Notch signaling pathway and in the pathogenesis of Alzheimer's Disease. There are two highly homologous presenilin genes in mammals, presenilin 1 (PS1) and presenilin 2 (PS2). In mice, inactivat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Donoviel, Dorit B., Hadjantonakis, Anna-Katerina, Ikeda, Masaki, Zheng, Hui, Hyslop, Peter St George, Bernstein, Alan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 1999
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC317124/
https://ncbi.nlm.nih.gov/pubmed/10557208
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