Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects

Genetic studies in worms, flies, and humans have implicated the presenilins in the regulation of the Notch signaling pathway and in the pathogenesis of Alzheimer's Disease. There are two highly homologous presenilin genes in mammals, presenilin 1 (PS1) and presenilin 2 (PS2). In mice, inactivat...

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Autores principales: Donoviel, Dorit B., Hadjantonakis, Anna-Katerina, Ikeda, Masaki, Zheng, Hui, Hyslop, Peter St George, Bernstein, Alan
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1999
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC317124/
https://ncbi.nlm.nih.gov/pubmed/10557208
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