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The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity
Genetic studies have shown that ubiquitination and endocytosis of the Drosophila ligand Delta in signal-sending cells are required for activation of Notch signaling, but how these events promote Notch activation remains poorly understood. Here, we show that an ubiquitination-defective mutant of the...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516222/ https://ncbi.nlm.nih.gov/pubmed/18676613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800695105 |
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