The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity

Genetic studies have shown that ubiquitination and endocytosis of the Drosophila ligand Delta in signal-sending cells are required for activation of Notch signaling, but how these events promote Notch activation remains poorly understood. Here, we show that an ubiquitination-defective mutant of the...

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Main Authors: Heuss, Sara Farrah, Ndiaye-Lobry, Delphine, Six, Emmanuelle M., Israël, Alain, Logeat, Frédérique
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516222/
https://ncbi.nlm.nih.gov/pubmed/18676613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800695105
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