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Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor
Activation of mammalian Notch receptor by its ligands induces TNFα-converting enzyme–dependent ectodomain shedding, followed by intramembrane proteolysis due to presenilin (PS)-dependent γ-secretase activity. Here, we demonstrate that a new modification, a monoubiquitination, as well as clathrin-dep...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172142/ https://ncbi.nlm.nih.gov/pubmed/15240571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200310098 |
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