Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor

Activation of mammalian Notch receptor by its ligands induces TNFα-converting enzyme–dependent ectodomain shedding, followed by intramembrane proteolysis due to presenilin (PS)-dependent γ-secretase activity. Here, we demonstrate that a new modification, a monoubiquitination, as well as clathrin-dep...

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Detaylı Bibliyografya
Asıl Yazarlar: Gupta-Rossi, Neetu, Six, Emmanuelle, LeBail, Odile, Logeat, Frédérique, Chastagner, Patricia, Olry, Annie, Israël, Alain, Brou, Christel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2004
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172142/
https://ncbi.nlm.nih.gov/pubmed/15240571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200310098
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