A Glycosphingolipid Binding Domain Controls Trafficking and Activity of the Mammalian Notch Ligand Delta-Like 1

The activity of Notch ligands is tightly regulated by trafficking events occurring both before and after ligand-receptor interaction. In particular endocytosis and recycling have been shown to be required for full signaling activity of the ligands before they encounter the Notch receptor. However li...

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Main Authors: Heuss, Sara Farrah, Tarantino, Nadine, Fantini, Jacques, Ndiaye-Lobry, Delphine, Moretti, Julien, Israël, Alain, Logeat, Frédérique
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771905/
https://ncbi.nlm.nih.gov/pubmed/24069306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074392
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