Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4

The biological antagonism between the signaling proteins Numb and Notch has been implicated in the regulation of many developmental processes, especially in asymmetric cell division. Mechanistic studies show that Numb inactivates Notch via endocytosis and proteasomal degradation that directly reduce...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Shao, Ximing, Ding, Zhihao, Zhao, Ming, Liu, Ke, Sun, Haiyan, Chen, Juntao, Liu, Xianming, Zhang, Yuzhen, Hong, Yang, Li, Huashun, Li, Hongchang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733598/
https://ncbi.nlm.nih.gov/pubmed/29042443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.800946
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