Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4

The biological antagonism between the signaling proteins Numb and Notch has been implicated in the regulation of many developmental processes, especially in asymmetric cell division. Mechanistic studies show that Numb inactivates Notch via endocytosis and proteasomal degradation that directly reduce...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Shao, Ximing, Ding, Zhihao, Zhao, Ming, Liu, Ke, Sun, Haiyan, Chen, Juntao, Liu, Xianming, Zhang, Yuzhen, Hong, Yang, Li, Huashun, Li, Hongchang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733598/
https://ncbi.nlm.nih.gov/pubmed/29042443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.800946
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