Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4

The biological antagonism between the signaling proteins Numb and Notch has been implicated in the regulation of many developmental processes, especially in asymmetric cell division. Mechanistic studies show that Numb inactivates Notch via endocytosis and proteasomal degradation that directly reduce...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Shao, Ximing, Ding, Zhihao, Zhao, Ming, Liu, Ke, Sun, Haiyan, Chen, Juntao, Liu, Xianming, Zhang, Yuzhen, Hong, Yang, Li, Huashun, Li, Hongchang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733598/
https://ncbi.nlm.nih.gov/pubmed/29042443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.800946
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