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The NHR1 Domain of Neuralized Binds Delta and Mediates Delta Trafficking and Notch Signaling

Notch signaling, which is crucial to metazoan development, requires endocytosis of Notch ligands, such as Delta and Serrate. Neuralized is a plasma membrane-associated ubiquitin ligase that is required for neural development and Delta internalization. Neuralized is comprised of three domains that in...

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Hlavní autoři: Commisso, Cosimo, Boulianne, Gabrielle L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751308/
https://ncbi.nlm.nih.gov/pubmed/17065551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-08-0753
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