The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Processing

γ-Secretase is an enzyme complex that mediates both Notch signaling and β-amyloid precursor protein (APP) processing, resulting in the generation of Notch intracellular domain, APP intracellular domain, and the amyloid β peptide (Aβ), the latter playing a central role in Alzheimer disease (AD). By a...

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Detalhes bibliográficos
Main Authors: Wanngren, Johanna, Frånberg, Jenny, Svensson, Annelie I., Laudon, Hanna, Olsson, Fredrik, Winblad, Bengt, Liu, Frank, Näslund, Jan, Lundkvist, Johan, Karlström, Helena
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838274/
https://ncbi.nlm.nih.gov/pubmed/20106965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055590
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