γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42)/Aβ(40) ratio

Lignende værker

• γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
  af: Masayasu Okochi, et al.
  Udgivet: (2013-01-01)
• Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase
  af: Sun, Linfeng, et al.
  Udgivet: (2017)
• Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ
  af: Fernandez, Marty A., et al.
  Udgivet: (2014)
• Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations
  af: Wanngren, Johanna, et al.
  Udgivet: (2014)
• Presenilin/γ-Secretase Cleaves CD46 in Response to Neisseria Infection
  af: Weyand, Nathan J., et al.
  Udgivet: (2009)