Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations

The enzyme complex γ-secretase generates amyloid β-peptide (Aβ), a 37–43-residue peptide associated with Alzheimer disease (AD). Mutations in presenilin 1 (PS1), the catalytical subunit of γ-secretase, result in familial AD (FAD). A unifying theme among FAD mutations is an alteration in the ratio Aβ...

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Main Authors: Wanngren, Johanna, Lara, Patricia, Öjemalm, Karin, Maioli, Silvia, Moradi, Nasim, Chen, Lu, Tjernberg, Lars O., Lundkvist, Johan, Nilsson, IngMarie, Karlström, Helena
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050182/
https://ncbi.nlm.nih.gov/pubmed/24918054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.04.006
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