Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing

Bằng Pamrén, Annelie, Wanngren, Johanna, Tjernberg, Lars O., Winblad, Bengt, Bhat, Ratan, Näslund, Jan, Karlström, Helena
Được phát hành 2011

The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Process...

Bằng Wanngren, Johanna, Frånberg, Jenny, Svensson, Annelie I., Laudon, Hanna, Olsson, Fredrik, Winblad, Bengt, Liu, Frank, Näslund, Jan, Lundkvist, Johan, Karlström, Helena
Được phát hành 2010

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations

Bằng Wanngren, Johanna, Lara, Patricia, Öjemalm, Karin, Maioli, Silvia, Moradi, Nasim, Chen, Lu, Tjernberg, Lars O., Lundkvist, Johan, Nilsson, IngMarie, Karlström, Helena
Được phát hành 2014

Second Generation γ-Secretase Modulators Exhibit Different Modulation of Notch β and Aβ Production

Bằng Wanngren, Johanna, Ottervald, Jan, Parpal, Santiago, Portelius, Erik, Strömberg, Kia, Borgegård, Tomas, Klintenberg, Rebecka, Juréus, Anders, Blomqvist, Jenny, Blennow, Kaj, Zetterberg, Henrik, Lundkvist, Johan, Rosqvist, Susanne, Karlström, Helena
Được phát hành 2012

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

Bằng Pigoni, Martina, Wanngren, Johanna, Kuhn, Peer-Hendrik, Munro, Kathryn M., Gunnersen, Jenny M., Takeshima, Hiroshi, Feederle, Regina, Voytyuk, Iryna, De Strooper, Bart, Levasseur, Mikail D., Hrupka, Brian J., Müller, Stephan A., Lichtenthaler, Stefan F.
Xuất bản năm Mol Neurodegener (2016)

γ-secretase directly sheds the survival receptor BCMA from plasma cells

Bằng Laurent, Sarah A., Hoffmann, Franziska S., Kuhn, Peer-Hendrik, Cheng, Qingyu, Chu, Yuanyuan, Schmidt-Supprian, Marc, Hauck, Stefanie M., Schuh, Elisabeth, Krumbholz, Markus, Rübsamen, Heike, Wanngren, Johanna, Khademi, Mohsen, Olsson, Tomas, Alexander, Tobias, Hiepe, Falk, Pfister, Hans-Walter, Weber, Frank, Jenne, Dieter, Wekerle, Hartmut, Hohlfeld, Reinhard, Lichtenthaler, Stefan F., Meinl, Edgar
Xuất bản năm Nat Commun (2015)

Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy

Bằng Borgegård, Tomas, Gustavsson, Susanne, Nilsson, Charlotte, Parpal, Santiago, Klintenberg, Rebecka, Berg, Anna-Lena, Rosqvist, Susanne, Serneels, Lutgarde, Svensson, Samuel, Olsson, Fredrik, Jin, Shaobo, Yan, Hongmei, Wanngren, Johanna, Jureus, Anders, Ridderstad-Wollberg, Anna, Wollberg, Patrik, Stockling, Kenneth, Karlström, Helena, Malmberg, Åsa, Lund, Johan, Arvidsson, Per I., De Strooper, Bart, Lendahl, Urban, Lundkvist, Johan
Xuất bản năm J Neurosci (2012)