Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

BACKGROUND: The protease BACE1 (beta-site APP cleaving enzyme) is a major drug target in Alzheimer’s disease. However, BACE1 therapeutic inhibition may cause unwanted adverse effects due to its additional functions in the nervous system, such as in myelination and neuronal connectivity. Additionally...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Pigoni, Martina, Wanngren, Johanna, Kuhn, Peer-Hendrik, Munro, Kathryn M., Gunnersen, Jenny M., Takeshima, Hiroshi, Feederle, Regina, Voytyuk, Iryna, De Strooper, Bart, Levasseur, Mikail D., Hrupka, Brian J., Müller, Stephan A., Lichtenthaler, Stefan F.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053352/
https://ncbi.nlm.nih.gov/pubmed/27716410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0134-z
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