BACE2 distribution in major brain cell types and identification of novel substrates

β-Site APP-cleaving enzyme 1 (BACE1) inhibition is considered one of the most promising therapeutic strategies for Alzheimer’s disease, but current BACE1 inhibitors also block BACE2. As the localization and function of BACE2 in the brain remain unknown, it is difficult to predict whether relevant si...

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Publicat a:Life Sci Alliance
Autors principals: Voytyuk, Iryna, Mueller, Stephan A, Herber, Julia, Snellinx, An, Moechars, Dieder, van Loo, Geert, Lichtenthaler, Stefan F, De Strooper, Bart
Format: Artigo
Idioma:Inglês
Publicat: Life Science Alliance LLC 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238391/
https://ncbi.nlm.nih.gov/pubmed/30456346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800026
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