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BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer’s Disease Markers in Elderly Healthy Participants

The β-site amyloid-β protein precursor (AβPP) cleaving enzyme-1 (BACE1) is the rate limiting enzyme in the generation of amyloid-β peptide (Aβ) from AβPP, one of the major pathways in Alzheimer’s disease (AD) pathology. Increased BACE1 levels and activity have been reported in the brain of patients...

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Detaylı Bibliyografya
Yayımlandı:J Alzheimers Dis
Asıl Yazarlar: Timmers, Maarten, Barão, Soraia, Van Broeck, Bianca, Tesseur, Ina, Slemmon, John, De Waepenaert, Katja, Bogert, Jennifer, Shaw, Leslie M., Engelborghs, Sebastiaan, Moechars, Dieder, Mercken, Marc, Van Nueten, Luc, Tritsmans, Luc, de Strooper, Bart, Streffer, Johannes Rolf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: IOS Press 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325057/
https://ncbi.nlm.nih.gov/pubmed/28157093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-160829
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