Impact of frequent cerebrospinal fluid sampling on Aβ levels: systematic approach to elucidate influencing factors

BACKGROUND: Cerebrospinal fluid (CSF) amyloid-beta (Aβ) peptides are predictive biomarkers for Alzheimer’s disease and are proposed as pharmacodynamic markers for amyloid-lowering therapies. However, frequent sampling results in fluctuating CSF Aβ levels that have a tendency to increase compared wit...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Van Broeck, Bianca, Timmers, Maarten, Ramael, Steven, Bogert, Jennifer, Shaw, Leslie M., Mercken, Marc, Slemmon, John, Van Nueten, Luc, Engelborghs, Sebastiaan, Streffer, Johannes Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875639/
https://ncbi.nlm.nih.gov/pubmed/27206648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-016-0184-z
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