Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

BACKGROUND: The protease BACE1 (beta-site APP cleaving enzyme) is a major drug target in Alzheimer’s disease. However, BACE1 therapeutic inhibition may cause unwanted adverse effects due to its additional functions in the nervous system, such as in myelination and neuronal connectivity. Additionally...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Neurodegener
Egile Nagusiak: Pigoni, Martina, Wanngren, Johanna, Kuhn, Peer-Hendrik, Munro, Kathryn M., Gunnersen, Jenny M., Takeshima, Hiroshi, Feederle, Regina, Voytyuk, Iryna, De Strooper, Bart, Levasseur, Mikail D., Hrupka, Brian J., Müller, Stephan A., Lichtenthaler, Stefan F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053352/
https://ncbi.nlm.nih.gov/pubmed/27716410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0134-z
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