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γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42)/Aβ(40) ratio
Markers for caspase activation and apoptosis have been shown in brains of Alzheimer’s disease (AD) patients and AD-mouse models. In neurons, caspase activation is associated with elevated amyloid β-peptide (Aβ) production. Caspases cleave numerous substrates including presenilin-1 (PS1). The cleavag...
में बचाया:
| में प्रकाशित: | J Cell Mol Med |
|---|---|
| मुख्य लेखकों: | , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Blackwell Publishing Ltd
2011
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394225/ https://ncbi.nlm.nih.gov/pubmed/21054783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2010.01208.x |
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