γ-Secretase Dependent Production of Intracellular Domains Is Reduced in Adult Compared to Embryonic Rat Brain Membranes

BACKGROUND: γ-Secretase is an intramembrane aspartyl protease whose cleavage of the amyloid precursor protein (APP) generates the amyloid β-peptide (Aβ) and the APP intracellular domain. Aβ is widely believed to have a causative role in Alzheimer's disease pathogenesis, and therefore modulation...

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Detaylı Bibliyografya
Asıl Yazarlar: Frånberg, Jenny, Karlström, Helena, Winblad, Bengt, Tjernberg, Lars O., Frykman, Susanne
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841641/
https://ncbi.nlm.nih.gov/pubmed/20333303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009772
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