Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation – Application on γ-Secretase

Here, we present a highly sensitive method to study protein-protein interactions and subcellular location selectively for active multicomponent enzymes. We apply the method on γ-secretase, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid β-pep...

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Detalhes bibliográficos
Main Authors: Schedin-Weiss, Sophia, Inoue, Mitsuhiro, Teranishi, Yasuhiro, Yamamoto, Natsuko Goto, Karlström, Helena, Winblad, Bengt, Tjernberg, Lars O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663845/
https://ncbi.nlm.nih.gov/pubmed/23717518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063962
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