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Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse
The transmembrane protein assembly γ-secretase is a key protease in regulated intramembrane processing (RIP) of around 100 type-1 transmembrane proteins. Importantly, it has a pathological role in Alzheimer disease (AD) as it generates the neurotoxic amyloid β-peptide from the amyloid precursor prot...
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| Publicado no: | Acta Neuropathol Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4818506/ https://ncbi.nlm.nih.gov/pubmed/27036709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0296-5 |
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