Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

γ-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer’s disease and cancer. While its structure is atomically resolved, γ-secretase localization in the membrane in situ relies mostly on biochemical data. Here, we combined fluorescent tagging of γ-secretase subuni...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Escamilla-Ayala, Abril Angélica, Sannerud, Ragna, Mondin, Magali, Poersch, Karin, Vermeire, Wendy, Paparelli, Laura, Berlage, Caroline, Koenig, Marcelle, Chavez-Gutierrez, Lucia, Ulbrich, Maximilian H, Munck, Sebastian, Mizuno, Hideaki, Annaert, Wim
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2020
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340497/
https://ncbi.nlm.nih.gov/pubmed/32631487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56679
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