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Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface
γ-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer’s disease and cancer. While its structure is atomically resolved, γ-secretase localization in the membrane in situ relies mostly on biochemical data. Here, we combined fluorescent tagging of γ-secretase subuni...
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| 出版年: | eLife |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7340497/ https://ncbi.nlm.nih.gov/pubmed/32631487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56679 |
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