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Presenilins and γ-Secretase in Membrane Proteostasis
The presenilin (PS) proteins exert a crucial role in the pathogenesis of Alzheimer disease (AD) by mediating the intramembranous cleavage of amyloid precursor protein (APP) and the generation of amyloid β-protein (Aβ). The two homologous proteins PS1 and PS2 represent the catalytic subunits of disti...
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| Veröffentlicht in: | Cells |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6468700/ https://ncbi.nlm.nih.gov/pubmed/30823664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8030209 |
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