Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum

γ-Secretase affects many physiological processes through targeting >100 substrates; malfunctioning links γ-secretase to cancer and Alzheimer’s disease. The spatiotemporal regulation of its stoichiometric assembly remains unresolved. Fractionation, biochemical assays, and imaging support prior for...

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Bibliographic Details
Published in:J Cell Biol
Main Authors: Wouters, Rosanne, Michiels, Christine, Sannerud, Ragna, Kleizen, Bertrand, Dillen, Katleen, Vermeire, Wendy, Ayala, Abril Escamilla, Demedts, David, Schekman, Randy, Annaert, Wim
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302450/
https://ncbi.nlm.nih.gov/pubmed/34292306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201911104
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