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Biogenesis of γ-secretase early in the secretory pathway
γ-Secretase is responsible for proteolytic maturation of signaling and cell surface proteins, including amyloid precursor protein (APP). Abnormal processing of APP by γ-secretase produces a fragment, Aβ(42), that may be responsible for Alzheimer's disease (AD). The biogenesis and trafficking of...
Tallennettuna:
| Päätekijät: | , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The Rockefeller University Press
2007
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2099203/ https://ncbi.nlm.nih.gov/pubmed/18056412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200709012 |
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