Spatial Segregation of γ-Secretase and Substrates in Distinct Membrane Domains

γ-Secretase facilitates the regulated intramembrane proteolysis of select type I membrane proteins that play diverse physiological roles in multiple cell types and tissue. In this study, we used biochemical approaches to examine the distribution of amyloid precursor protein (APP) and several additio...

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Bibliographic Details
Main Authors: Vetrivel, Kulandaivelu S., Cheng, Haipeng, Kim, Seong-Hun, Chen, Ying, Barnes, Natalie Y., Parent, Ange‘le T., Sisodia, Sangram S., Thinakaran, Gopal
Format: Artigo
Language:Inglês
Published: 2005
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201532/
https://ncbi.nlm.nih.gov/pubmed/15886206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M503570200
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