Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes

Alzheimer’s disease-associated β-amyloid peptides (Aβ) are generated by the sequential proteolytic processing of amyloid precursor protein (APP) by β- and γ-secretases. There is growing evidence that cholesterol- and sphingolipid-rich membrane microdomains are involved in regulating trafficking and...

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Main Authors: Vetrivel, Kulandaivelu S., Cheng, Haipeng, Lin, William, Sakurai, Takashi, Li, Tong, Nukina, Nobuyuki, Wong, Philip C., Xu, Huaxi, Thinakaran, Gopal
Format: Artigo
Sprog:Inglês
Udgivet: 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201506/
https://ncbi.nlm.nih.gov/pubmed/15322084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M407986200
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