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Mechanisms of Disease: new therapeutic strategies for Alzheimer’s disease—targeting amyloid precursor protein processing in lipid rafts
Alzheimer’s disease (AD) is the most common cause of age-related dementia. Pathologically, AD is characterized by the deposition in the brain of amyloid-β peptides derived from proteolysis of amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) andγ-secretase. Growing evidence imp...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880530/ https://ncbi.nlm.nih.gov/pubmed/17611486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncpneuro0549 |
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