Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function

Por Parent, Angèle T., Thinakaran, Gopal
Publicado em 2010

APP receptor? To be or not to be…

Por Deyts, Carole, Thinakaran, Gopal, Parent, Angèle T.
Publicado no Trends Pharmacol Sci (2016)

Mechanisms of Disease: new therapeutic strategies for Alzheimer’s disease—targeting amyloid precursor protein processing in lipid rafts

Por Cheng, Haipeng, Vetrivel, Kulandaivelu S., Gong, Ping, Parent, Angèle, Thinakaran, Gopal
Publicado em 2007

Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons

Por Barnes, Natalie Y., Shi, Jun, Yajima, Hiroshi, Thinakaran, Gopal, Parent, Angèle T.
Publicado em 2007

Loss of presenilin function is associated with a selective gain of APP function

Por Deyts, Carole, Clutter, Mary, Herrera, Stacy, Jovanovic, Natalia, Goddi, Anna, Parent, Angèle T
Publicado no eLife (2016)

Localization and regional distribution of p23/TMP21 in the brain

Por Vetrivel, Kulandaivelu S., Kodam, Anitha, Gong, Ping, Chen, Ying, Parent, Angèle T., Kar, Satyabrata, Thinakaran, Gopal
Publicado em 2008

Novel Gα(S)-Protein Signaling Associated with Membrane-Tethered Amyloid Precursor Protein Intracellular Domain

Por Deyts, Carole, Vetrivel, Kulandaivelu S., Das, Shibandri, Shepherd, Yumiko M., Dupré, Denis J., Thinakaran, Gopal, Parent, Angèle T.
Publicado em 2012

Stringently regulated p23 expression is critical for coordinated movement in mice: implications for Alzheimer’s disease

Por Gong, Ping, Roseman, Jelita, Vetrivel, Kulandaivelu S, Bindokas, Vytautas P, Zitzow, Lois A, Kar, Satyabrata, Parent, Angèle T, Thinakaran, Gopal
Publicado em 2012

Spatial Segregation of γ-Secretase and Substrates in Distinct Membrane Domains

Por Vetrivel, Kulandaivelu S., Cheng, Haipeng, Kim, Seong-Hun, Chen, Ying, Barnes, Natalie Y., Parent, Ange‘le T., Sisodia, Sangram S., Thinakaran, Gopal
Publicado em 2005

Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates

Por Gong, Ping, Vetrivel, Kulandaivelu S., Nguyen, Phuong D., Meckler, Xavier, Cheng, Haipeng, Kounnas, Maria Z., Wagner, Steven L., Parent, Angèle T., Thinakaran, Gopal
Publicado em 2010

Reduced Alzheimer's Disease β-Amyloid Deposition in Transgenic Mice Expressing S-Palmitoylation-Deficient APH1aL and Nicastrin

Por Meckler, Xavier, Roseman, Jelita, Das, Pritam, Cheng, Haipeng, Pei, Susan, Keat, Marcia, Kassarjian, Breanne, Golde, Todd E., Parent, Angèle T., Thinakaran, Gopal
Publicado em 2010

Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice

Por Gong, Ping, Roseman, Jelita, Fernandez, Celia G, Vetrivel, Kulandaivelu S, Bindokas, Vytautas P, Zitzow, Lois A, Kar, Satyabrata, Parent, Angèle T, Thinakaran, Gopal
Publicado em 2011

d-Serine is an endogenous ligand for the glycine site of the N-methyl-d-aspartate receptor

Por Mothet, Jean-Pierre, Parent, Angèle T., Wolosker, Herman, Brady, Roscoe O., Linden, David J., Ferris, Christopher D., Rogawski, Michael A., Snyder, Solomon H.
Publicado em 2000

Evidence That CD147 Modulation of β-Amyloid (Aβ) Levels Is Mediated by Extracellular Degradation of Secreted Aβ

Por Vetrivel, Kulandaivelu S., Zhang, Xulun, Meckler, Xavier, Cheng, Haipeng, Lee, Sungho, Gong, Ping, Lopes, Kryslaine O., Chen, Ying, Iwata, Nobuhisa, Yin, Ke-Jie, Lee, Jin-Moo, Parent, Angèle T., Saido, Takaomi C., Li, Yue-Ming, Sisodia, Sangram S., Thinakaran, Gopal
Publicado em 2008

Regulation of dynamic BACE1 trafficking in neurons

Por Buggia-Prévot, Virginie, Fernandez, Celia G, Riordan, Sean, Vetrivel, Kulandaivelu S, Udayar, Vinod, Elie, Aureliane, Lefkow, Margaret, Roseman, Jelita, Meckler, Xavier, Bhattacharyya, Sohinee, George, Manju, Waters, Jack, Bindokas, Vytautas P, Parent, Angèle T, Rajendran, Lawrence, Band, Hamid, Vassar, Robert, Thinakaran, Gopal
Publicado em 2013

A Novel Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer's disease Aβ production

Por Buggia-Prévot, Virginie, Fernandez, Celia G., Udayar, Vinod, Vetrivel, Kulandaivelu S., Elie, Aureliane, Roseman, Jelita, Sasse, Verena A., Lefkow, Margaret, Meckler, Xavier, Bhattacharyya, Sohinee, George, Manju, Kar, Satyabrata, Bindokas, Vytautas P., Parent, Angèle T., Rajendran, Lawrence, Band, Hamid, Vassar, Robert, Thinakaran, Gopal
Publicado em 2013

Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts

Por De Rossi, Pierre, Buggia-Prévot, Virginie, Clayton, Benjamin L. L., Vasquez, Jared B., van Sanford, Carson, Andrew, Robert J., Lesnick, Ruben, Botté, Alexandra, Deyts, Carole, Salem, Someya, Rao, Eshaan, Rice, Richard C., Parent, Angèle, Kar, Satyabrata, Popko, Brian, Pytel, Peter, Estus, Steven, Thinakaran, Gopal
Publicado no Mol Neurodegener (2016)

Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease

Por Andrew, Robert J., Fernandez, Celia G., Stanley, Molly, Jiang, Hong, Nguyen, Phuong, Rice, Richard C., Buggia-Prévot, Virginie, De Rossi, Pierre, Vetrivel, Kulandaivelu S., Lamb, Raza, Argemi, Arnau, Allaert, Emilie S., Rathbun, Elle M., Krause, Sofia V., Wagner, Steven L., Parent, Angèle T., Holtzman, David M., Thinakaran, Gopal
Publicado no Proc Natl Acad Sci U S A (2017)