Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by pathological brain lesions and a decline in cognitive function. β-Amyloid peptides (Aβ), derived from proteolytic processing of amyloid precursor protein (APP), play a central role in AD pathogenesis. β-Site APP cl...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Andrew, Robert J., Fernandez, Celia G., Stanley, Molly, Jiang, Hong, Nguyen, Phuong, Rice, Richard C., Buggia-Prévot, Virginie, De Rossi, Pierre, Vetrivel, Kulandaivelu S., Lamb, Raza, Argemi, Arnau, Allaert, Emilie S., Rathbun, Elle M., Krause, Sofia V., Wagner, Steven L., Parent, Angèle T., Holtzman, David M., Thinakaran, Gopal
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692556/
https://ncbi.nlm.nih.gov/pubmed/29078331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708568114
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