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Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons

Neurons have developed elaborate mechanisms for sorting of proteins to their destination in dendrites and axons as well as dynamic local trafficking. Recent evidence suggests that polarized axonal sorting of β-site converting enzyme 1 (BACE1), a type I transmembrane aspartyl protease involved in Alz...

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Bibliografski detalji
Izdano u:Bioessays
Glavni autori: Buggia-Prévot, Virginie, Thinakaran, Gopal
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512854/
https://ncbi.nlm.nih.gov/pubmed/26126792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201500019
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