Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

BACKGROUND: BACE1 is one of the two enzymes that cleave amyloid precursor protein to generate Alzheimer's disease (AD) beta amyloid peptides. It is widely believed that BACE1 initiates APP processing in endosomes, and in the brain this cleavage is known to occur during axonal transport of APP....

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Hlavní autoři: Buggia-Prévot, Virginie, Fernandez, Celia G, Riordan, Sean, Vetrivel, Kulandaivelu S, Roseman, Jelita, Waters, Jack, Bindokas, Vytautas P, Vassar, Robert, Thinakaran, Gopal
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031619/
https://ncbi.nlm.nih.gov/pubmed/24386896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-1
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