Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

BACKGROUND: BACE1 is one of the two enzymes that cleave amyloid precursor protein to generate Alzheimer's disease (AD) beta amyloid peptides. It is widely believed that BACE1 initiates APP processing in endosomes, and in the brain this cleavage is known to occur during axonal transport of APP....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Buggia-Prévot, Virginie, Fernandez, Celia G, Riordan, Sean, Vetrivel, Kulandaivelu S, Roseman, Jelita, Waters, Jack, Bindokas, Vytautas P, Vassar, Robert, Thinakaran, Gopal
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031619/
https://ncbi.nlm.nih.gov/pubmed/24386896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-1
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados