A Novel Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer's disease Aβ production

Abnormal accumulation of β-secretase (BACE1) in dystrophic neurites and presynaptic β-amyloid (Aβ) production contribute to Alzheimer's disease pathogenesis. Little, however, is known about BACE1 dynamic transport in neurons. We investigated BACE1 trafficking in hippocampal neurons using live-c...

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Hauptverfasser: Buggia-Prévot, Virginie, Fernandez, Celia G., Udayar, Vinod, Vetrivel, Kulandaivelu S., Elie, Aureliane, Roseman, Jelita, Sasse, Verena A., Lefkow, Margaret, Meckler, Xavier, Bhattacharyya, Sohinee, George, Manju, Kar, Satyabrata, Bindokas, Vytautas P., Parent, Angèle T., Rajendran, Lawrence, Band, Hamid, Vassar, Robert, Thinakaran, Gopal
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932704/
https://ncbi.nlm.nih.gov/pubmed/24373286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.006
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