A Novel Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer's disease Aβ production

Abnormal accumulation of β-secretase (BACE1) in dystrophic neurites and presynaptic β-amyloid (Aβ) production contribute to Alzheimer's disease pathogenesis. Little, however, is known about BACE1 dynamic transport in neurons. We investigated BACE1 trafficking in hippocampal neurons using live-c...

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Main Authors: Buggia-Prévot, Virginie, Fernandez, Celia G., Udayar, Vinod, Vetrivel, Kulandaivelu S., Elie, Aureliane, Roseman, Jelita, Sasse, Verena A., Lefkow, Margaret, Meckler, Xavier, Bhattacharyya, Sohinee, George, Manju, Kar, Satyabrata, Bindokas, Vytautas P., Parent, Angèle T., Rajendran, Lawrence, Band, Hamid, Vassar, Robert, Thinakaran, Gopal
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932704/
https://ncbi.nlm.nih.gov/pubmed/24373286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.006
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