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Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

BACKGROUND: BACE1 is one of the two enzymes that cleave amyloid precursor protein to generate Alzheimer's disease (AD) beta amyloid peptides. It is widely believed that BACE1 initiates APP processing in endosomes, and in the brain this cleavage is known to occur during axonal transport of APP....

詳細記述

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書誌詳細
主要な著者: Buggia-Prévot, Virginie, Fernandez, Celia G, Riordan, Sean, Vetrivel, Kulandaivelu S, Roseman, Jelita, Waters, Jack, Bindokas, Vytautas P, Vassar, Robert, Thinakaran, Gopal
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031619/
https://ncbi.nlm.nih.gov/pubmed/24386896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-1
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