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Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase
BACKGROUND: BACE1 is one of the two enzymes that cleave amyloid precursor protein to generate Alzheimer's disease (AD) beta amyloid peptides. It is widely believed that BACE1 initiates APP processing in endosomes, and in the brain this cleavage is known to occur during axonal transport of APP....
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4031619/ https://ncbi.nlm.nih.gov/pubmed/24386896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-1 |
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