Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons

Mutations in the genes encoding presenilins (PS1 and PS2) account for the majority of cases of early-onset Alzheimer’s disease. PS1 and PS2 form the catalytic center of γ-secretase, an enzyme responsible for intramembraneous proteolysis of several type I transmembrane proteins. Many γ-secretase subs...

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Detaylı Bibliyografya
Asıl Yazarlar: Barnes, Natalie Y., Shi, Jun, Yajima, Hiroshi, Thinakaran, Gopal, Parent, Angèle T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2598774/
https://ncbi.nlm.nih.gov/pubmed/17996025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.05102.x
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