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Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons
Mutations in the genes encoding presenilins (PS1 and PS2) account for the majority of cases of early-onset Alzheimer’s disease. PS1 and PS2 form the catalytic center of γ-secretase, an enzyme responsible for intramembraneous proteolysis of several type I transmembrane proteins. Many γ-secretase subs...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2598774/ https://ncbi.nlm.nih.gov/pubmed/17996025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.05102.x |
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