Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function

Mutations in PSEN genes, which encode presenilin proteins, cause familial early-onset Alzheimer's disease (AD). Transgenic mouse models based on coexpression of familial AD-associated presenilin and amyloid precursor protein variants successfully mimic characteristic pathological features of AD...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Parent, Angèle T., Thinakaran, Gopal
Materialtyp: Artigo
Språk:Inglês
Publicerad: SAGE-Hindawi Access to Research 2010
Ämnen:
Review Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925324/
https://ncbi.nlm.nih.gov/pubmed/20798900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/825918
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