Evidence That CD147 Modulation of β-Amyloid (Aβ) Levels Is Mediated by Extracellular Degradation of Secreted Aβ

Cerebral deposition of β-amyloid (Aβ) peptides is a pathological hallmark of Alzheimer disease. Intramembranous proteolysis of amyloid precursor protein by a multiprotein γ-secretase complex generates Aβ. Previously, it was reported that CD147, a glycoprotein that stimulates production of matrix met...

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Main Authors: Vetrivel, Kulandaivelu S., Zhang, Xulun, Meckler, Xavier, Cheng, Haipeng, Lee, Sungho, Gong, Ping, Lopes, Kryslaine O., Chen, Ying, Iwata, Nobuhisa, Yin, Ke-Jie, Lee, Jin-Moo, Parent, Angèle T., Saido, Takaomi C., Li, Yue-Ming, Sisodia, Sangram S., Thinakaran, Gopal
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443668/
https://ncbi.nlm.nih.gov/pubmed/18456655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801037200
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