Restricted location of PSEN2 γ-secretase determines substrate specificity and generates an intracellular Aβ pool

γ-Secretases are a family of intramembrane cleaving proteases involved in various signaling pathways and diseases, including Alzheimer’s disease (AD). Cells co-express differing γ-secretase complexes, including two homologous presenilins (PSEN). We examined the significance of this heterogeneity and...

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Publicado no:Cell
Main Authors: Sannerud, Ragna, Esselens, Cary, Ejsmont, Paulina, Mattera, Rafael, Rochin, Leila, Tharkeshwar, Arun Kumar, Baets, Greet De, De Wever, Veerle, Habets, Roger, Baert, Veerle, Vermeire, Wendy, Michiels, Christine, Groot, Arjan J., Wouters, Rosanne, Dillen, Katleen, Vints, Katlijn, Baatsen, Pieter, Munck, Sebastian, Derua, Rita, Waelkens, Etienne, Basi, Guriqbal S., Mercken, Mark, Vooijs, Marc, Bollen, Mathieu, Schymkowitz, Joost, Rousseau, Frederic, Bonifacino, Juan S., Van Niel, Guillaume, De Strooper, Bart, Annaert, Wim
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439524/
https://ncbi.nlm.nih.gov/pubmed/27293189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.020
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