ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

Amyloid β (Aβ) peptides, the primary constituents of senile plaques and a hallmark in Alzheimer's disease pathology, are generated through the sequential cleavage of amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase. The early endosome is thought to represe...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Sannerud, Ragna, Declerck, Ilse, Peric, Aleksandar, Raemaekers, Tim, Menendez, Guillermo, Zhou, Lujia, Veerle, Baert, Coen, Katrijn, Munck, Sebastian, De Strooper, Bart, Schiavo, Giampietro, Annaert, Wim
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161548/
https://ncbi.nlm.nih.gov/pubmed/21825135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100745108
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky