The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo

The β-site amyloid precursor protein-cleaving enzyme BACE1 is a prime drug target for Alzheimer disease. However, the function and the physiological substrates of BACE1 remain largely unknown. In this work, we took a quantitative proteomic approach to analyze the secretome of primary neurons after a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Zhou, Lujia, Barão, Soraia, Laga, Mathias, Bockstael, Katrijn, Borgers, Marianne, Gijsen, Harry, Annaert, Wim, Moechars, Diederik, Mercken, Marc, Gevaer, Kris, De Strooper, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406677/
https://ncbi.nlm.nih.gov/pubmed/22692213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377465
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados