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Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum
γ-Secretase affects many physiological processes through targeting >100 substrates; malfunctioning links γ-secretase to cancer and Alzheimer’s disease. The spatiotemporal regulation of its stoichiometric assembly remains unresolved. Fractionation, biochemical assays, and imaging support prior for...
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| Publicado en: | J Cell Biol |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Rockefeller University Press
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8302450/ https://ncbi.nlm.nih.gov/pubmed/34292306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201911104 |
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