Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels

BACKGROUND: Increased levels of the pathogenic amyloid β-peptide (Aβ), released from its precursor by the transmembrane protease γ-secretase, are found in Alzheimer disease (AD) brains. Interestingly, monoamine oxidase B (MAO-B) activity is also increased in AD brain, but its role in AD pathogenesis...

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Publicado en:Alzheimers Res Ther
Autores principales: Schedin-Weiss, Sophia, Inoue, Mitsuhiro, Hromadkova, Lenka, Teranishi, Yasuhiro, Yamamoto, Natsuko Goto, Wiehager, Birgitta, Bogdanovic, Nenad, Winblad, Bengt, Sandebring-Matton, Anna, Frykman, Susanne, Tjernberg, Lars O.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540560/
https://ncbi.nlm.nih.gov/pubmed/28764767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-017-0279-1
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