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Synaptic and Endosomal Localization of Active γ-Secretase in Rat Brain
BACKGROUND: A key player in the development of Alzheimer's disease (AD) is the γ-secretase complex consisting of at least four components: presenilin, nicastrin, Aph-1 and Pen-2. γ-Secretase is crucial for the generation of the neurotoxic amyloid β-peptide (Aβ) but also takes part in the proces...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2812513/ https://ncbi.nlm.nih.gov/pubmed/20126630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008948 |
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